SopE and SopE 2 from S . typhimurium activate different sets of RhoGTPases of the host cell
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چکیده
¶ Corresponding author: Wolf-Dietrich Hardt, Max von Pettenkofer-Institut, Ludwig Maximilians Universität, Pettenkoferstr. 9a, 80336 München, Germany. fax: 89-5160-5223, phone: 89-5160-5263, e-mail: [email protected] *This work was supported by grants from the Deutsche Forschungsgemeinschaft (Nachwuchsgruppe of WDH; BIAcore 2000-work: Sonderforschungsbereich 469 of the LMU München, grant A-6/Machleidt)
منابع مشابه
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.
The bacterial enteropathogen Salmonella typhimurium employs a type III secretion system to inject bacterial toxins into the host cell cytosol. These toxins transiently activate Rho family GTP-binding protein-dependent signaling cascades to induce cytoskeletal rearrangements. One of these translocated Salmonella toxins, SopE, can activate Cdc42 in a Dbl-like fashion despite its lack of sequence ...
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RhoGTPases are central switches in all eukaryotic cells. There are at least two known families of guanine nucleotide exchange factors that can activate RhoGTPases: the Dbl-like eukaryotic G nucleotide exchange factors and the SopE-like toxins of pathogenic bacteria, which are injected into host cells to manipulate signaling. Both families have strikingly different sequences, structures, and cat...
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تاریخ انتشار 2001